Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells.

@article{Osanai2007EpigeneticSO,
  title={Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells.},
  author={Makoto Osanai and Masaki Murata and Hideki Chiba and Takashi Kojima and Norimasa Sawada},
  journal={Cancer science},
  year={2007},
  volume={98 10},
  pages={1557-62}
}
Cancer cells often exhibit loss of functional tight junctions (TJ), and disruption of the TJ structure is associated with cancer development. However, whether loss of a certain type of claudin, an integral membrane protein of TJ, is involved in malignant phenotypes remains to be clarified. Based on a report that claudin-6 functions as a tumor suppressor for breast cancer, the authors show here that suppression of claudin-6 expression results in increased resistance to various apoptogens, and… CONTINUE READING

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