Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation

  title={Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation},
  author={Ji Cui and Y. Cai and Ying Hu and Zenghong Huang and Yanxin Luo and Andrew M. Kaz and Zihuan Yang and Dianke Chen and Xinjuan Fan and William M. Grady and Jianping Wang},
  journal={Tumor Biology},
Beta-tropomyosin (β-tropomyosin, TPM2) has been found to be downregulated in colorectal cancer (CRC) in previous studies. In this study, we aimed to investigate the mechanisms and potential biological consequences of the downregulation of TPM2 in colorectal cancer. TPM2 expression in colorectal cancer was assessed by qRT-PCR and immunostaining. The biological functions of TPM2 were assessed in cell lines either overexpressing or underexpressingTPM2. Aberrant DNA methylation in the promoter… CONTINUE READING


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