Epigenetic silencing of MIR203 in multiple myeloma.

  title={Epigenetic silencing of MIR203 in multiple myeloma.},
  author={Kwan Yeung Wong and Raymond Liang and C. K. So and Dong-Yan Jin and Joseph F. Costello and Chor Sang Chim},
  journal={British journal of haematology},
  volume={154 5},
Epigenetic inactivation of tumour suppressor microRNAs has been implicated in carcinogenesis. We studied the promoter methylation of MIR203 in eight normal marrow controls, eight multiple myeloma (MM) cell lines, 20 monoclonal gammopathy of undetermined significance (MGUS), 123 diagnostic MM and 19 relapsed MM samples by methylation-specific polymerase chain reaction. Promoter of MIR203 was unmethylated in normal controls but homozygously methylated in 25% MM cell lines. Treatment with 5-Aza-2… CONTINUE READING
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