Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma.


Wnt/β-Catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1-DKK4) has been shown to be important in Wnt signaling regulation. In this study, the role of DKK2, a Wnt antagonist, in epithelial ovarian cancer (EOC) was evaluated by examining the expression and methylation of DKK2… (More)
DOI: 10.1093/carcin/bgs278


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Citations per Year

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