Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol.

@article{Chung2007EpigeneticSO,
  title={Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol.},
  author={Ivy Chung and Adam R. Karpf and Josephia R. Muindi and Jeffrey M. Conroy and Norma J. Nowak and Candace S. Johnson and Donald L. Trump},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 12},
  pages={8704-14}
}
Calcitriol (1,25-dihydroxycholecalciferol), the most active form of vitamin D, has selective anti-proliferative effects on tumor-derived endothelial cells (TDEC) compared with Matrigel-derived endothelial cells (MDEC). Although both cell types have an intact vitamin D receptor-signaling axis, this study demonstrates that upon treatment with calcitriol, 24-hydroxylase (CYP24) mRNA, protein and enzymatic activity were markedly induced in MDEC in a time-dependent manner but not in TDEC… CONTINUE READING
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