Epigenetic silencing mediated through activated PI3K/AKT signaling in breast cancer.


Trimethylation of histone 3 lysine 27 (H3K27me3) is a critical epigenetic mark for the maintenance of gene silencing. Additional accumulation of DNA methylation in target loci is thought to cooperatively support this epigenetic silencing during tumorigenesis. However, molecular mechanisms underlying the complex interplay between the two marks remain to be… (More)
DOI: 10.1158/0008-5472.CAN-10-3573


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