Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer

@article{Metge2008EpigeneticSC,
  title={Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer},
  author={Brandon J. Metge and Andra R. Frost and Judy A. C. King and Donna Lynn Dyess and Danny R Welch and Rajeev S Samant and Lalita A. Shevde},
  journal={Clinical & Experimental Metastasis},
  year={2008},
  volume={25},
  pages={753-763}
}
Breast Cancer Metastasis Suppressor 1 (BRMS1) suppresses metastasis of human breast cancer, ovarian cancer and melanoma in athymic mice. Studies have also shown that BRMS1 is significantly downregulated in some breast tumors, especially in metastatic disease. However, the mechanisms which regulate BRMS1 expression are currently unknown. Upon examination of the BRMS1 promoter region by methylation specific PCR (MSP) analysis, we discovered a CpG island (−3477 to −2214), which was found to be… CONTINUE READING
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