Epigenetic reprogramming of human embryonic stem cells into skeletal muscle cells and generation of contractile myospheres.

@article{Albini2013EpigeneticRO,
  title={Epigenetic reprogramming of human embryonic stem cells into skeletal muscle cells and generation of contractile myospheres.},
  author={S. Mark Albini and Paula Coutinho and Barbora Malecova and Lorenzo Giordani and Alexei Savchenko and Sonia Vanina Forcales and Pier Lorenzo Puri},
  journal={Cell reports},
  year={2013},
  volume={3 3},
  pages={
          661-70
        }
}
Direct generation of a homogeneous population of skeletal myoblasts from human embryonic stem cells (hESCs) and formation of three-dimensional contractile structures for disease modeling in vitro are current challenges in regenerative medicine. Previous studies reported on the generation of myoblasts from ESC-derived embryoid bodies (EB), but not from undifferentiated ESCs, indicating the requirement for mesodermal transition to promote skeletal myogenesis. Here, we show that selective absence… CONTINUE READING
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