Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract.

@article{Freberg2007EpigeneticRO,
  title={Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract.},
  author={Christel T Freberg and John Arne Dahl and Sanna Timoskainen and Philippe Collas},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 5},
  pages={
          1543-53
        }
}
Analyses of molecular events associated with reprogramming somatic nuclei to pluripotency are scarce. We previously reported the reprogramming of epithelial cells by extract of undifferentiated embryonal carcinoma (EC) cells. We now demonstrate reprogramming of DNA methylation and histone modifications on regulatory regions of the developmentally regulated OCT4 and NANOG genes by exposure of 293T cells to EC cell extract. OCT4 and NANOG are transcriptionally up-regulated and undergo mosaic… CONTINUE READING
98 Citations
45 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 98 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

from mouse embryonic and adult fibroblast cultures by defined factors

  • C. K. Taranger, A. Noer, A. L. Sorensen, A. M. Hakelien, A. C. Boquest, P. Collas
  • 2005
Highly Influential
12 Excerpts

Similar Papers

Loading similar papers…