Epigenetic reprogramming and induced pluripotency.

@article{Hochedlinger2009EpigeneticRA,
  title={Epigenetic reprogramming and induced pluripotency.},
  author={Konrad Hochedlinger and Kathrin Plath},
  journal={Development},
  year={2009},
  volume={136 4},
  pages={509-23}
}
The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte. More recently, transcription factors have been identified that can induce pluripotency in somatic cells without the use of oocytes, generating induced pluripotent stem (iPS) cells. iPS cells provide a unique platform to dissect the molecular mechanisms that underlie epigenetic reprogramming. Moreover… CONTINUE READING
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