Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

@inproceedings{DelgadoOlgun2012EpigeneticRO,
  title={Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis},
  author={Paul Delgado-Olgu{\'i}n and Yu Huang and Xue Li and Danos C. Christodoulou and Christine E Seidman and J G Seidman and Alexander Tarakhovsky and Benoit G Bruneau},
  booktitle={Nature Genetics},
  year={2012}
}
Adult-onset diseases can be associated with in utero events, but mechanisms for this remain unknown. The Polycomb histone methyltransferase Ezh2 stabilizes transcription by depositing repressive marks during development that persist into adulthood, but its function in postnatal organ homeostasis is unknown. We show that Ezh2 stabilizes cardiac gene expression and prevents cardiac pathology by repressing the homeodomain transcription factor gene Six1, which functions in cardiac progenitor cells… CONTINUE READING
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