Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

@inproceedings{Lara2010EpigeneticRO,
  title={Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer},
  author={Ester Lara and Vincenzo Calvanese and Covadonga Huidobro and Agust{\'i}n F Fern{\'a}ndez and {\'A}ngela Moncada-Pazos and Alvaro J Obaya and Oscar Aguilera and Jos{\'e} Manuel Gonz{\'a}lez-Sancho and L F Cerd{\'a}n S{\'a}nchez and Aurora Astudillo and Alberto Mu{\~n}oz and Carlos L{\'o}pez-Ot{\'i}n and Manel Esteller and Mario F Fraga},
  booktitle={Molecular Cancer},
  year={2010}
}
Wnt factors control cell differentiation through semi-independent molecular cascades known as the β-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways. Genetic and epigenetic alteration of components of the canonical Wnt signalling pathway is one of the primary mechanisms underlying colon cancer. Despite increasing evidence of the role of the non-canonical pathways in tumourigenesis, however, the underlying molecular mechanisms are poorly understood. Here we… CONTINUE READING

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