Epigenetic repression of PDZ-LIM domain-containing protein 2 promotes ovarian cancer via NOS2-derived nitric oxide signaling.

@article{Zhao2016EpigeneticRO,
  title={Epigenetic repression of PDZ-LIM domain-containing protein 2 promotes ovarian cancer via NOS2-derived nitric oxide signaling.},
  author={Linjie Zhao and Chuan Yu and Shengtao Zhou and Wayne Bond Lau and Bonnie K Lau and Zhongyue Luo and Qiao Lin and Huiliang Yang and Yu Xuan and Tao Yi and Xia Zhao and Yu-Quan Wei},
  journal={Oncotarget},
  year={2016},
  volume={7 2},
  pages={
          1408-20
        }
}
Ovarian cancer constitutes one of the most lethal gynaecological malignancies worldwide and currently no satisfactory therapeutic approaches have been established. Therefore, elucidation of molecular mechanisms to develop targeted therapy of ovarian cancer is crucial. PDLIM2 is critical to promote ubiquitination of nuclear p65 and thus its role in inflammation has been highlighted recently. We demonstrate that PDLIM2 is decreased in both ovarian high-grade serous carcinoma and in various human… CONTINUE READING

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