Epigenetic regulation of vascular endothelial gene expression.

  title={Epigenetic regulation of vascular endothelial gene expression.},
  author={C C Matouk and Philip A. Marsden},
  journal={Circulation research},
  volume={102 8},
Epigenetics refers to chromatin-based pathways important in the regulation of gene expression and includes 3 distinct, but highly interrelated, mechanisms: DNA methylation, histone density and posttranslational modifications, and RNA-based mechanisms. Together, they offer a newer perspective on transcriptional control paradigms in vascular endothelial cells and provide a molecular basis for how the environment impacts the genome to modify disease susceptibility. This review provides an… CONTINUE READING
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