Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.

@article{Hellebrekers2006EpigeneticRO,
  title={Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.},
  author={Debby M. E. I. Hellebrekers and Karolien Castermans and Emmanuelle Vir{\'e} and Ruud P M Dings and Nicole T. H. Hoebers and Kevin H. Mayo and Mirjam G. A. oude Egbrink and Grietje Molema and François Fuks and Manon van Engeland and Arjan W Griffioen},
  journal={Cancer research},
  year={2006},
  volume={66 22},
  pages={10770-7}
}
Tumors can escape from immunity by repressing leukocyte adhesion molecule expression on tumor endothelial cells and by rendering endothelial cells unresponsive to inflammatory activation. This endothelial cell anergy is induced by angiogenic growth factors and results in reduced leukocyte-vessel wall interactions, thereby attenuating infiltration of leukocytes into the tumor. This report describes a novel mechanism of endothelial cell anergy regulation. We recently reported that DNA… CONTINUE READING

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