Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer.

@article{Smith2006EpigeneticRO,
  title={Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer.},
  author={Laura T. Smith and Mauting Lin and Romulo Martin Brena and James Campbell Lang and David E. Schuller and Gregory Alan Otterson and Carl D. Morrison and Dominic J. Smiraglia and Christoph Plass},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 4},
  pages={982-7}
}
The identification of tumor suppressor genes has classically depended on their localization within recurrent regions of loss of heterozygosity. According to Knudson's two-hit hypothesis, the remaining allele is lost, either genetically or, more recently identified, through epigenetic events. To date, retrospective analyses have determined promoter methylation as a common alternative alteration in cancer cells to silence cancer-related genes. Here we report an application of restriction landmark… CONTINUE READING
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