Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells.

@article{Li2008EpigeneticRO,
  title={Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells.},
  author={Xuekun Li and Basam Z. Barkho and Yuping Luo and Richard D. Smrt and Nicholas J. Santistevan and Changmei Liu and Tomoko Kuwabara and Fred H. Gage and Xikai Zhao},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 41},
  pages={27644-52}
}
Whether and how mechanisms intrinsic to stem cells modulate their proliferation and differentiation are two central questions in stem cell biology. Although exogenous basic fibroblast growth factor 2 (FGF-2/Fgf-2) is commonly used to expand adult neural stem/progenitor cells (NSPCs) in vitro, we do not yet understand the functional significance or the molecular regulation of Fgf-2 expressed endogenously by adult NSPCs. We previously demonstrated that methylated CpG binding protein 1 (MBD1/Mbd1… CONTINUE READING
47 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Regulation of Fgf-2 in Adult NSPCs 27652 JOURNAL OF BIOLOGICAL CHEMISTRY

  • M. Spivakov, A. G. Fisher
  • Nat. Rev. Genet
  • 2007

Mbd1 Regulation of Fgf-2 in Adult

  • K. Dennis, T. Fan, T. Geiman, Q. Yan, K. andMuegge
  • NSPCs OCTOBER 10,
  • 2001

Similar Papers

Loading similar papers…