Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

@inproceedings{Hashizume2015EpigeneticRO,
  title={Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects},
  author={Osamu Hashizume and Sakiko Ohnishi and Takayuki Mito and Akinori Shimizu and Kaori Ishikawa and Kazuto Nakada and Manabu Soda and Hiroyuki Mano and Sumie Togayachi and Hiroyuki Miyoshi and Keisuke Okita and Jun-ichi Hayashi},
  booktitle={Scientific reports},
  year={2015}
}
Age-associated accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for the age-associated mitochondrial respiration defects found in elderly human subjects. We carried out reprogramming of human fibroblast lines derived from elderly subjects by generating their induced pluripotent stem cells (iPSCs), and examined another possibility, namely that these aging phenotypes are controlled not by mutations but by epigenetic regulation. Here, we show that… CONTINUE READING
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