Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

@article{McGowan2009EpigeneticRO,
  title={Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse},
  author={Patrick O McGowan and Aya Sasaki and Ana C. D'Alessio and Sergiy Dymov and Benoit Labont{\'e} and Moshe Szyf and Gustavo Turecki and Michael J. Meaney},
  journal={Nature Neuroscience},
  year={2009},
  volume={12},
  pages={342-348}
}
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stress responses and increases the risk of suicide. We examined epigenetic differences in a neuron-specific glucocorticoid receptor (NR3C1) promoter between postmortem hippocampus obtained from suicide victims with a history of childhood abuse and those from either suicide victims with no childhood abuse or… CONTINUE READING
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