Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1.

@article{Tzeng2007EpigeneticRO,
  title={Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1.},
  author={Tsai-Yu Tzeng and Chi-Hua Lee and L. Chan and C J Shen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 31},
  pages={12691-6}
}
The polytene chromosomes of Drosophila melanogaster consist of condensed heterochromatin regions most of which are in the chromocenter, telomeres, and the fourth chromosome. Whereas suppressor of variegation 3-9 [SU(VAR)3-9], a histone methyltransferase, is mainly responsible for lysine 9 of histone H3 (H3K9) methylation of the chromocenter and consequent binding of the heterochromatin-protein HP1, the enzyme for painting of the fourth chromosome by H3K9 methylation has been elusive. We show… CONTINUE READING
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