Epigenetic regulation of the BDNF gene: implications for psychiatric disorders

  title={Epigenetic regulation of the BDNF gene: implications for psychiatric disorders},
  author={Fabien Boulle and Daniel L. Van den Hove and Segl Jakob and Bart P. F. Rutten and Michel Hamon and Jim van Os and K. Peter Lesch and Laurence Lanfumey and Harry W. M. Steinbusch and Gunter R L Kenis},
  journal={Molecular Psychiatry},
Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in the course and development of various neurological and psychiatric disorders. In addition, positive effects of psychotropic drugs are known to activate BDNF-mediated signaling. Although the BDNF gene has been associated with several diseases, molecular mechanisms other than functional genetic variations can impact on the regulation of BDNF gene expression and lead to disturbed BDNF signaling and… CONTINUE READING
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