Epigenetic regulation of microRNAs in acute lymphoblastic leukemia.

@article{RomnGmez2009EpigeneticRO,
  title={Epigenetic regulation of microRNAs in acute lymphoblastic leukemia.},
  author={Jos{\'e} Rom{\'a}n-G{\'o}mez and Xabier Agirre and Antonio Jim{\'e}nez-Velasco and V{\'i}ctor Arqueros and Amaia Vilas-Zornoza and Paula Rodr{\'i}guez-Otero and I{\~n}aki Martin-Subero and Leire G{\'a}rate and Lucia Cordeu and Edurne San Jos{\'e}-En{\'e}riz and Vanesa Sendin Martin and Juan Antonio Castillejo and Eva Bandrés and Mar{\'i}a Jos{\'e} Calasanz and Reiner Siebert and Anabel Heiniger and Antonio Alatorre Torres and Felipe Prosper},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 8},
  pages={
          1316-22
        }
}
PURPOSE To identify microRNAs (miRNAs) epigenetically regulated in acute lymphoblastic leukemia (ALL). METHODS We first examined ALL-derived cell lines for the presence of abnormal levels of two different histone modifications (trimethylation of H3 lysine 4 [K4H3me3] and dimethylation of H3 lysine 9 [K9H3me2]) in the 5'UTR regions around CpG islands of 78 miRNAs by chromatin immunoprecipitation (ChIP)-on-ChIP analysis. Methylation status (methylation-specific polymerase chain reaction [PCR… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 53 CITATIONS

DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancer.

  • Cancer biology & therapy
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

MicroRNA in Glioblastoma: An Overview

  • International journal of genomics
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 2 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2005
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2008
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…