Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential.

@article{Ferraro2014EpigeneticRO,
  title={Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential.},
  author={Angelo Ferraro and Christos K Kontos and Themis Boni and Ioannis Bantounas and Dimitra Siakouli and Vivian Kosmidou and Margarita Vlassi and Yannis Spyridakis and Iraklis Tsipras and George Nikolaos Zografos and Alexander Pintzas},
  journal={Epigenetics},
  year={2014},
  volume={9 1},
  pages={129-41}
}
Previous studies have uncovered several transcription factors that determine biological alterations in tumor cells to execute the invasion-metastasis cascade, including the epithelial-mesenchymal transition (EMT). We sought to investigate the role of miR-21 in colorectal cancer regulation. For this purpose, miR-21 expression was quantified in a panel of colorectal cancer cell lines and clinical specimens. High expression was found in cell lines with EMT properties and in the vast majority of… CONTINUE READING
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