Epigenetic regulation of mammalian stem cells.

  title={Epigenetic regulation of mammalian stem cells.},
  author={Xuekun Li and Xikai Zhao},
  journal={Stem cells and development},
  volume={17 6},
Two critical properties of stem cells are self-renewal and multipotency. The maintenance of their "stemness" state and commitment to differentiation are therefore tightly controlled by intricate molecular networks. Epigenetic mechanisms, including DNA methylation, chromatin remodeling and the noncoding RNA-mediated process, have profound regulatory roles in mammalian gene expression. Recent studies have shown that epigenetic regulators are key players in stem cell biology and their dysfunction… CONTINUE READING