Epigenetic regulation of inflammation in localized aggressive periodontitis

  title={Epigenetic regulation of inflammation in localized aggressive periodontitis},
  author={Luciana M Shaddox and A. F. Mullersman and H. Huang and Shannon Margaret Wallet and Taimour Y Langaee and Ikramuddin Aukhil},
  booktitle={Clinical Epigenetics},
We have previously demonstrated a Toll-like receptor (TLR)-mediated hyper-responsive phenotype in our cohort of localized aggressive periodontitis (LAP) individuals. However, mechanisms related to this phenotype are still not clear in the literature. The objective of this cross-sectional study is to examine the role of epigenetic regulation, specifically DNA methylation status of genes in the TLR pathway in this cohort. Peripheral blood was collected from 20 LAP patients and 20 healthy… CONTINUE READING
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