Epigenetic regulation of hypoxia-responsive gene expression: focusing on chromatin and DNA modifications.

@article{Tsai2014EpigeneticRO,
  title={Epigenetic regulation of hypoxia-responsive gene expression: focusing on chromatin and DNA modifications.},
  author={Ya-Ping Tsai and Kou-Juey Wu},
  journal={International journal of cancer},
  year={2014},
  volume={134 2},
  pages={249-56}
}
Mammalian cells constantly encounter hypoxia, which is a stress condition occurring during development and physiological processes. To adapt to this inevitable condition, cells develop various mechanisms to cope with this stress and survive. In addition to the activation/stabilization of transcriptional regulators (hypoxia-inducible factors), other epigenetic mechanisms of gene regulation are used. These mechanisms are mediated by various players including transcriptional coregulators… CONTINUE READING

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