Epigenetic regulation of heterochromatic DNA stability.

@article{Peng2008EpigeneticRO,
  title={Epigenetic regulation of heterochromatic DNA stability.},
  author={Jamy C. Peng and Gary H. Karpen},
  journal={Current opinion in genetics & development},
  year={2008},
  volume={18 2},
  pages={
          204-11
        }
}
In this review we summarize recent studies that demonstrate the importance of epigenetic mechanisms for maintaining genome integrity, specifically with respect to repeated DNAs within heterochromatin. Potential problems that arise during replication, recombination, and repair of repeated sequences are counteracted by post-translational histone modifications and associated proteins, including the cohesins. These factors appear to ensure repeat stability by multiple mechanisms: suppressing… CONTINUE READING
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