Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.

@article{Saleque2007EpigeneticRO,
  title={Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.},
  author={Shireen Saleque and Jonghwan Kim and Heather M. Rooke and Stuart H Orkin},
  journal={Molecular cell},
  year={2007},
  volume={27 4},
  pages={562-72}
}
Gfi-1 and Gfi-1b are homologous transcriptional repressors involved in diverse developmental contexts, including hematopoiesis and oncogenesis. Transcriptional repression by Gfi proteins requires the conserved SNAG domain. To elucidate the function of Gfi proteins, we purified Gfi-1b complexes and identified interacting proteins. Prominent among these is the corepressor CoREST, the histone demethylase LSD1, and HDACs 1 and 2. CoREST and LSD1 associate with Gfi-1/1b via the SNAG repression… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
119 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 119 extracted citations

Similar Papers

Loading similar papers…