Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system.

@article{Hong2015EpigeneticRO,
  title={Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system.},
  author={Shuangsong Hong and Gen Zheng and John W. Wiley},
  journal={Gastroenterology},
  year={2015},
  volume={148 1},
  pages={148-157.e7}
}
BACKGROUND & AIMS Chronic stress alters the hypothalamic-pituitary-adrenal axis, increases gut motility, and increases the perception of visceral pain. We investigated whether epigenetic mechanisms regulate chronic stress-induced visceral pain in the peripheral nervous systems of rats. METHODS Male rats were subjected to 1 hour of water avoidance stress each day, or given daily subcutaneous injections of corticosterone, for 10 consecutive days. L4-L5 and L6-S2 dorsal root ganglia (DRG) were… CONTINUE READING
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