Epigenetic regulation of genes in learning and memory.

@article{Roth2010EpigeneticRO,
  title={Epigenetic regulation of genes in learning and memory.},
  author={Tania L Roth and Eric D. Roth and J David Sweatt},
  journal={Essays in biochemistry},
  year={2010},
  volume={48 1},
  pages={
          263-74
        }
}
Rapid advances in the field of epigenetics are revealing a new way to understand how we can form and store strong memories of significant events in our lives. Epigenetic modifications of chromatin, namely the post-translational modifications of nuclear proteins and covalent modification of DNA that regulate gene activity in the CNS (central nervous system), continue to be recognized for their pivotal role in synaptic plasticity and memory formation. At the same time, studies are correlating… 
View on PubMed
essays.biochemistry.org
33 Citations
Background Citations
16
Methods Citations
1

Figures from this paper

33 Citations

Citation Type

Citation Type

Tip off the HAT– Epigenetic control of learning and memory by Drosophila Tip60
TLDR
It is demonstrated that increasing levels of Tip60 in the MB rescues learning and memory deficits resulting from Alzheimer's disease associated amyloid precursor protein (APP) induced neurodegeneration and highlights the potential of HAT activators as a therapeutic option for cognitive disorders.
Novel Higher-Order Epigenetic Regulation of the Bdnf Gene upon Seizures
TLDR
It is demonstrated that activation-dependent architectural remodeling of the neuronal cell nucleus in vivo contributes to activity-dependent changes in gene expression in the brain.
Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides.
Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition
TLDR
It is demonstrated that disruption of Tip60 HAT/HDAC2 homeostasis occurs early in the AD Drosophila brain and triggers epigenetic repression of neuroplasticity genes well before Aβ plaques form in male and female larvae.
HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model
TLDR
The present findings show feasibility for epigenetic mechanisms to control neural plasticity underlying the formation of specific memories for conspecific communication sounds in zebra finches.
The potential of epigenetics in stress-enhanced fear learning models of PTSD.
TLDR
The results of the animal studies discussed here highlight neuroepigenetics as an essential area for future research in the context of PTSD through SEFL studies, because of its potential to identify novel candidates for neurotherapeutics targeting stress-induced pathogenic memories.
Activity-regulated genes as mediators of neural circuit plasticity
Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain
TLDR
This study provides the first evidence that a broad spectrum of histone modifications may be involved in brain aging, and suggests that both DR and rapamycin may slow aging process in mouse brain via these underlying epigenetic mechanisms.
The role of DNA methylation in the mechanisms of memory reconsolidation and development of amnesia
Epigenetic programming of the neuroendocrine stress response by adult life stress.
TLDR
An overview of the growing body of literature describing the epigenetic modulation of the (primarily neuroendocrine) stress response as a consequence of adult life stress is provided and the implications for, and the challenges involved in applying this knowledge to, the identification and treatment of stress-related psychiatric disorders are interpreted.
...
...

References

SHOWING 1-10 OF 44 REFERENCES
Regulation of chromatin structure in memory formation
Epigenetic codes in cognition and behaviour
Epigenetic dysregulation in cognitive disorders
TLDR
This review outlines major cognitive disorders known to be associated with epigenetic dysregulation, and discusses the potential of ‘epigenetic medicine’ as a promising cure.
Decoding the Epigenetic Language of Neuronal Plasticity
Epigenetic mechanisms in the dentate gyrus act as a molecular switch in hippocampus-associated memory formation
TLDR
It is proposed that formation of enduring memories of significant events requires an interaction of GRs with the NMDA/ERK/MSK1/Elk-1 signaling pathways to allow an optimal epigenomic activation pattern in dentate gyrus neurons to accommodate their altered neurophysiological function.
Covalent Modification of DNA Regulates Memory Formation
Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory
TLDR
Results suggest epigenetic modification of the bdnf gene as a mechanism for isoform-specific gene readout during memory consolidation in the hippocampus suggests selective changes in gene expression are required for long-term memory formation.
Epigenetic mechanisms in schizophrenia.
DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity
Recovery of learning and memory is associated with chromatin remodelling
TLDR
It is shown that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred, and suggests that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment.
...
...