Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

@article{Jaenisch2003EpigeneticRO,
  title={Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals},
  author={Rudolf Jaenisch and Adrian Bird},
  journal={Nature Genetics},
  year={2003},
  volume={33 Suppl 1},
  pages={245-254}
}
Cells of a multicellular organism are genetically homogeneous but structurally and functionally heterogeneous owing to the differential expression of genes. Many of these differences in gene expression arise during development and are subsequently retained through mitosis. Stable alterations of this kind are said to be 'epigenetic', because they are heritable in the short term but do not involve mutations of the DNA itself. Research over the past few years has focused on two molecular… 
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References

SHOWING 1-10 OF 208 REFERENCES
Above and Within the Genome: Epigenetics Past and Present
  • F. Urnov, A. Wolffe
  • Biology, Medicine
    Journal of Mammary Gland Biology and Neoplasia
  • 2004
TLDR
The complex biochemistry of DNA methylation—the molecular basis of most epigenetic regulation in mammalian genomes—is described and data connecting it to targeted modification and remodeling of chromatin structure is reviewed.
Cytosine methylation and mammalian development.
TLDR
It is reported here that the methylation status of the 5' regions of a panel of tissue-specific genes could not be correlated with expression in tissues of fetal and newborn mice, suggesting that the numerous published expression-methylation correlations may have described not a cause but a consequence of transcriptional activation.
DNA hypermethylation in tumorigenesis: epigenetics joins genetics.
TLDR
Methylation changes constitute potentially sensitive molecular markers to define risk states, monitor prevention strategies, achieve early diagnosis, and track the prognosis of cancer.
The Role of DNA Methylation in Mammalian Epigenetics
TLDR
M Mammals appear to have taken advantage of the possibilities afforded by cytosine methylation to provide a heritable mechanism for altering DNA-protein interactions to assist in such silencing of X-linked and imprinted genes.
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
TLDR
The aberrant CpG island methylation can be used as a biomarker of malignant cells and as a predictor of their behaviour, and may constitute a good target for future therapies.
DNA methylation patterns and epigenetic memory.
  • A. Bird
  • Biology, Medicine
    Genes & development
  • 2002
TLDR
The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Epigenetics: regulation through repression.
TLDR
Epigenetics is the study of heritable changes in gene expression that occur without a change in DNA sequence, which can complicate the genetic manipulation of plants and animals.
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
TLDR
The results demonstrate that loss of Dnmt1 causes cell-type–specific changes in gene expression that impinge on several pathways, including expression of imprinted genes, cell-cycle control, growth factor/receptor signal transduction and mobilization of retroelements.
Molecular Mechanisms of Gene Silencing Mediated by DNA Methylation
TLDR
It is demonstrated that a few methylated cytosines can inhibit a flanking promoter but a threshold of modified sites is required to organize a stable, diffusible chromatin structure.
Methylation dynamics, epigenetic fidelity and X chromosome structure.
TLDR
DNA methylation of the X chromosome is reviewed and discussed, with emphasis on the partial methylation seen in the mouse X-linked Pgk1 promoter region, and chromatin accessibility differences between the active X chromosome (Xa) and the inactive X chromosomes (Xi).
...
1
2
3
4
5
...