Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

  title={Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals},
  author={R. Jaenisch and A. Bird},
  journal={Nature Genetics},
  volume={33 Suppl 1},
  • R. Jaenisch, A. Bird
  • Published 2003
  • Biology, Medicine
  • Nature Genetics
  • Cells of a multicellular organism are genetically homogeneous but structurally and functionally heterogeneous owing to the differential expression of genes. Many of these differences in gene expression arise during development and are subsequently retained through mitosis. Stable alterations of this kind are said to be 'epigenetic', because they are heritable in the short term but do not involve mutations of the DNA itself. Research over the past few years has focused on two molecular… CONTINUE READING
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