Epigenetic regulation of centromere formation and kinetochore function.

  title={Epigenetic regulation of centromere formation and kinetochore function.},
  author={Ryan J Heit and Darrell Alan Underhill and Gordon K. T. Chan and Michael J. Hendzel},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={84 4},
In the midst of an increasingly detailed understanding of the molecular basis of genome regulation, we still only vaguely understand the relationship between molecular biochemistry and the structure of the chromatin inside of cells. The centromere is a structurally and functionally unique region of each chromosome and provides an example in which the molecular understanding far exceeds the understanding of the structure and function relationships that emerge on the chromosomal scale. The… CONTINUE READING