Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer.

@article{Kagara2012EpigeneticRO,
  title={Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer.},
  author={Naofumi Kagara and Kelly T. Huynh and Christine Yeh Kuo and Hideyuki Okano and Myung Sim and David Elashoff and Kelly Yi Ying Chong and Armando E. Giuliano and Dave S B Hoon},
  journal={The American journal of pathology},
  year={2012},
  volume={181 1},
  pages={
          257-67
        }
}
Expression of specific breast cancer stem cells (BCSCs) is seen in aggressive tumors, but their regulation is unclear. Epigenetic changes influence gene expression and are implicated in breast cancer progression. We hypothesized that promoter methylation regulates specific BCSC-related genes [CD44, CD133, CD24, MSH1 (alias, Musashi-1), and ALDH1] and that this epigenetic profile can identify aggressive subtypes, such as triple-negative breast cancer (TNBC). Methylation analysis was performed… CONTINUE READING
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