Epigenetic regulation of TGF-β1 signalling in dilative aortopathy of the thoracic ascending aorta.

@article{Forte2016EpigeneticRO,
  title={Epigenetic regulation of TGF-β1 signalling in dilative aortopathy of the thoracic ascending aorta.},
  author={Amalia Forte and Umberto Galderisi and M. Cipollaro and Marisa de Feo and Alessandro Della Corte},
  journal={Clinical science},
  year={2016},
  volume={130 16},
  pages={1389-405}
}
The term 'epigenetics' refers to heritable, reversible DNA or histone modifications that affect gene expression without modifying the DNA sequence. Epigenetic modulation of gene expression also includes the RNA interference mechanism. Epigenetic regulation of gene expression is fundamental during development and throughout life, also playing a central role in disease progression. The transforming growth factor β1 (TGF-β1) and its downstream effectors are key players in tissue repair and… CONTINUE READING
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