Epigenetic regulation of MHC-II and CIITA genes.

  title={Epigenetic regulation of MHC-II and CIITA genes.},
  author={Kenneth L. Wright and Jenny P-Y Ting},
  journal={Trends in immunology},
  volume={27 9},
This review describes recent advances in understanding how epigenetic events control MHC-class-II-family (MHC-II) gene expression. To address this issue, two phases of gene transcription have to be considered. First, the control of MHC-II by chromatin-modifying events such as histone acetylation, methylation, deacetylation, ubiquitination and the interplay between these different epigenetic events will be examined. The interactions of chromatin-modifying enzymes with class II transactivator… CONTINUE READING