Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter.

  title={Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter.},
  author={Vinata B. Lokeshwar and Pablo G{\'o}mez and Mario Kramer and Judith Knapp and Melissa A McCornack and Luis Enrique Lopez and Nevis L. Fregien and Neetika Dhir and Steve W Scherer and David Jichael Klumpp and Murugesan Manoharan and Mark S. Soloway and Bal L. Lokeshwar},
  journal={The Journal of biological chemistry},
  volume={283 43},
HYAL-1 (hyaluronoglucosaminidase-1) belongs to the hyaluronidase family of enzymes that degrade hyaluronic acid. HYAL-1 is a marker for cancer diagnosis and a molecular determinant of tumor growth, invasion, and angiogenesis. The regulation of HYAL-1 expression is unknown. Real time reverse transcription-PCR using 11 bladder and prostate cancer cells and 69 bladder tissues showed that HYAL-1 mRNA levels are elevated 10-30-fold in cells/tissues that express high hyaluronidase activity. Although… CONTINUE READING
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