Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer

  title={Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer},
  author={Giulia Piazzi and Lucia Fini and Michael Selgrad and Melissa J Garcia and Yahya A H Daoud and Thomas Wex and P Malfertheiner and Antonio Gasbarrini and Marco Romano and Richard A. Meyer and R M Genta and James G Fox and Clement Richard Boland and Franco Bazzoli and Luigi Ricciardiello},
The Notch signaling pathway drives proliferation, differentiation, apoptosis, cell fate, and maintenance of stem cells in several tissues. Aberrant activation of Notch signaling has been described in several tumours and in gastric cancer (GC), activated Notch1 has been associated with de-differentiation of lineage-committed stomach cells into stem progenitors and GC progression. However, the specific role of the Notch1 ligand DLL1 in GC has not yet been elucidated. To assess the role of DLL1 in… CONTINUE READING


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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas

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