Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat.

@article{Dyrvig2012EpigeneticRO,
  title={Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat.},
  author={Mads Dyrvig and Henrik H. Hansen and S. Christiansen and David Paul Drucker Woldbye and Jens Damsgaard Mikkelsen and Jacek Lichota},
  journal={Brain research bulletin},
  year={2012},
  volume={88 5},
  pages={507-13}
}
Electroconvulsive stimulation (ECS) remains one of the most effective treatments of major depression. However, the underlying molecular changes still remain to be elucidated. Since ECS causes rapid and significant changes in gene expression we have looked at epigenetic regulation of two important immediate early genes that are both induced after ECS: c-Fos and Arc. We examined Arc and c-Fos protein expression and found Arc present over 4 h, in contrast to c-Fos presence lasting only 1 h. Both… CONTINUE READING
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