Epigenetic regulation during B cell differentiation controls CIITA promoter accessibility.

@article{Green2006EpigeneticRD,
  title={Epigenetic regulation during B cell differentiation controls CIITA promoter accessibility.},
  author={Myesha R. Green and Hyesuk Yoon and Jeremy M Boss},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={3865-73}
}
B cell to plasma cell maturation is marked by the loss of MHC class II expression. This loss is due to the silencing of the MHC class II transcriptional coactivator CIITA. In this study, experiments to identify the molecular mechanism responsible for CIITA silencing were conducted. CIITA is expressed from four promoters in humans, of which promoter III (pIII) controls the majority of B cell-mediated expression. Chromatin immunoprecipitation assays were used to establish the histone code for… CONTINUE READING

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