Epigenetic regulation by long noncoding RNAs.

  title={Epigenetic regulation by long noncoding RNAs.},
  author={Jeannie T Lee},
  volume={338 6113},
Recent studies show that transcription of the mammalian genome is not only pervasive but also enormously complex. It is estimated that an average of 10 transcription units, the vast majority of which make long noncoding RNAs (lncRNAs), may overlap each traditional coding gene. These lncRNAs include not only antisense, intronic, and intergenic transcripts but also pseudogenes and retrotransposons. Do they universally have function, or are they merely transcriptional by-products of conventional… CONTINUE READING
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Acknowledgments: I am very grateful to members of the RNA community and the laboratory for many excellent discussions

  • T. A. Manolio, N. Engl
  • J. Med. 363,
  • 2010
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