Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.

@article{Nguyen2016EpigeneticRB,
  title={Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.},
  author={Huong Nguyen and Godwin Sokpor and Linh Pham and Joachim Rosenbusch and Anastassia Stoykova and Jochen F. Staiger and Tran Tuoc},
  journal={Cell cycle},
  year={2016},
  volume={15 10},
  pages={
          1317-24
        }
}
The multi-subunit chromatin-remodeling SWI/SNF (known as BAF for Brg/Brm-associated factor) complexes play essential roles in development. Studies have shown that the loss of individual BAF subunits often affects local chromatin structure and specific transcriptional programs. However, we do not fully understand how BAF complexes function in development because no animal mutant had been engineered to lack entire multi-subunit BAF complexes. Importantly, we recently reported that double… CONTINUE READING
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