Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

@inproceedings{Li2012EpigeneticRO,
  title={Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer},
  author={Yuanyuan Li and Syed Mustapha Meeran and Shweta N. Patel and Huaping Chen and Tabitha M. Hardy and Trygve O. Tollefsbol},
  booktitle={Molecular Cancer},
  year={2012}
}
Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and normally does not respond to conventional estrogen target-directed therapies. The soybean isoflavone, genistein (GE), has been shown to prevent and inhibit breast cancer and recent studies have suggested that GE can enhance the anticancer capacity of an estrogen antagonist, tamoxifen (TAM), especially in ERα-positive breast cancer cells. However, the role of GE in ERα-negative breast cancer remains unknown. We have… CONTINUE READING
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A novel prodrug of epigallocatechin - 3 - gallate : differential epigenetic hTERT repression in human breast cancer cells

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