Epigenetic programming by maternal behavior

@article{Weaver2004EpigeneticPB,
  title={Epigenetic programming by maternal behavior},
  author={Ian C. G. Weaver and Nadia Cervoni and Frances A. Champagne and Ana C. D’Alessio and Shakti Sharma and Jonathan R Seckl and Sergiy Dymov and Moshe Szyf and Michael J. Meaney},
  journal={Nature Neuroscience},
  year={2004},
  volume={7},
  pages={847-854}
}
Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN) by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene promoter in the hippocampus. Offspring of mothers that showed high levels of LG and ABN were found to have differences in DNA methylation, as compared to offspring of 'low-LG-ABN' mothers. These differences emerged over the first week of life, were reversed with cross-fostering, persisted into adulthood and were… 

Figures from this paper

Epigenetic Programming by Maternal Behavior and Pharmacological Intervention Nature Versus Nurture: Let's Call The Whole Thing Off
TLDR
Research demonstrates that an epigenetic state of a gene can be established through early-in-life experience, and is potentially reversible in adulthood, as a major source of variation in biological and behavioral phenotypes.
Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
TLDR
It is reported that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary-adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GRexpression, and stress responses in the adult offspring.
Epigenetic effects of glucocorticoids.
  • I. Weaver
  • Biology
    Seminars in fetal & neonatal medicine
  • 2009
Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats
TLDR
These epigenetic and transcriptional profiles constitute the first tiling microarray data set exploring the relationship between epigenetic modifications and RNA expression in both protein coding and non-coding regions across a chromosomal locus in the mammalian brain.
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood.
  • I. Weaver, M. Meaney, M. Szyf
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
It is reported that TSA and methionine treatment reversed the effect of maternal care on open-field behavior, and >900 genes stably regulated by maternal care were identified.
Epigenetic Programming of Stress Responses and Trans-Generational Inheritance Through Natural Variations in Maternal Care
TLDR
Rodent models provide evidence that epigenetic mechanisms are involved: natural variations in maternal care influence HPA stress reactivity in offspring via long-term changes in tissue-specific gene expression, providing a potential mechanism to explain how physiological adaptations to changes in the early environment result in permanent programming and affect risk to disease later in life.
Within- and between-litter maternal care alter behavior and gene regulation in female offspring.
TLDR
Differences in the response to maternal care both within- and between-litters were distinct in part from previous reports of between litter effects, potentially a result of the sex studied or the methods used to observe maternal care.
Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans
TLDR
Evidence is reviewed suggesting that parental influences establish stable phenotypic variation in the offspring through effects on intracellular signaling pathways that regulate the epigenetic state and function of specific regions of the genome and new findings reveal associated histone post-translational modifications of a critical GR promoter in rat hippocampus.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat.
TLDR
It is suggested that maternal care during infancy serves to "program" behavioral responses to stress in the offspring by altering the development of the neural systems that mediate fearfulness.
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.
  • M. Meaney
  • Psychology, Biology
    Annual review of neuroscience
  • 2001
TLDR
Evidence is provided for the importance of parental care as a mediator of the effects of environmental adversity on neural development and patterns of maternal care that increase stress reactivity in offspring are enhanced by stressors imposed on the mother.
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.
TLDR
It is suggested that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.
Nongenomic transmission across generations of maternal behavior and stress responses in the rat.
TLDR
Results of cross-fostering studies reported here indicate that variations in maternal care can serve as the basis for a nongenomic behavioral transmission of individual differences in stress reactivity across generations.
The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factors a
  • S. Levine
  • Biology
    Annals of the New York Academy of Sciences
  • 1994
TLDR
Although the infant rat is capable of responding to stressful stimuli by day 15, circadian rhythmicity and feedback regulation are not yet fully developed until much later in development, the overall picture that emerges is that there are multiple differences in the neonatal neuroendocrine system that ensure that plasma CORT is suppressed.
Postnatal Handling Increases the Expression of cAMP-Inducible Transcription Factors in the Rat Hippocampus: The Effects of Thyroid Hormones and Serotonin
TLDR
Findings suggest that postnatal handling might alter glucocorticoid receptor gene expression via cAMP–PKA pathways involving the activation of NGFI-A and AP-2.
Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress.
TLDR
The findings indicate that the early postnatal environment alters the differentiation of hippocampal neurons, and these data provide examples of early environmental programming of neural systems.
Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat.
TLDR
It was found that H animals secreted less ACTH and corticosterone during and following the termination of stress than did nonhandled (NH) controls, and H animals were more sensitive than NH animals to the inhibitory effects of either B or dexamethasone on stress-induced adrenocortical activity.
...
1
2
3
4
...