Epigenetic programming by maternal behavior


Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN) by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene promoter in the hippocampus. Offspring of mothers that showed high levels of LG and ABN were found to have differences in DNA methylation, as compared to offspring of 'low-LG-ABN… (More)
DOI: 10.1038/nn1276


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@article{Weaver2004EpigeneticPB, title={Epigenetic programming by maternal behavior}, author={Ian C G Weaver and Nadia Cervoni and F. Champagne and Ana C. D'Alessio and Shakti Sharma and Jonathan R Seckl and Sergiy I Dymov and Moshe Szyf and Michael J. Meaney}, journal={Nature Neuroscience}, year={2004}, volume={7}, pages={847-854} }