Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.


Malignant pleural mesothelioma (MPM) is a fatal thoracic malignancy, the epigenetics of which are poorly defined. We performed high-throughput methylation analysis covering 6,157 CpG islands in 20 MPMs and 20 lung adenocarcinomas. Newly identified genes were further analyzed in 50 MPMs and 56 adenocarcinomas via quantitative methylation-specific PCR… (More)
DOI: 10.1158/0008-5472.CAN-09-1595


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