Epigenetic priors for identifying active transcription factor binding sites

@article{CuellarPartida2012EpigeneticPF,
  title={Epigenetic priors for identifying active transcription factor binding sites},
  author={Gabriel Cuellar-Partida and Fabian A. Buske and Robert C. McLeay and Tom Whitington and William Stafford Noble and Timothy L. Bailey},
  journal={Bioinformatics},
  year={2012},
  volume={28 1},
  pages={56-62}
}
MOTIVATION Accurate knowledge of the genome-wide binding of transcription factors in a particular cell type or under a particular condition is necessary for understanding transcriptional regulation. Using epigenetic data such as histone modification and DNase I, accessibility data has been shown to improve motif-based in silico methods for predicting such binding, but this approach has not yet been fully explored. RESULTS We describe a probabilistic method for combining one or more tracks of… CONTINUE READING