Epigenetic pathways and glioblastoma treatment

  title={Epigenetic pathways and glioblastoma treatment},
  author={Jennifer Clarke and Clara Penas and Chiara Pastori and Ricardo J. Komotar and Amade Bregy and Ashish Harish Shah and Claes Wahlestedt and Nagi George Ayad},
Glioblastoma multiforme (GBM) is the most common malignant adult brain tumor. Standard GBM treatment includes maximal safe surgical resection with combination radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. Alarmingly, patient survival at five-years is below 10%. This is in part due to the invasive behavior of the tumor and the resulting inability to resect greater than 98% of some tumors. In fact, recurrence after such treatment may be inevitable, even in cases where gross total… CONTINUE READING
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