Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer.

@article{Tada2006EpigeneticMO,
  title={Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer.},
  author={Yasuhiro Tada and Romulo Martin Brena and Bj{\"o}rn Hackanson and C India Morrison and Gregory Alan Otterson and Christoph Plass},
  journal={Journal of the National Cancer Institute},
  year={2006},
  volume={98 6},
  pages={396-406}
}
BACKGROUND Loss of tumor suppressor CCAAT/enhancer-binding protein-alpha (C/EBPalpha) expression is seen in several human malignancies, including acute myelogenous leukemia and lung cancer. We hypothesized that DNA methylation and histone acetylation of the C/EBPalpha promoter may modulate C/EBPalpha expression in lung cancer. METHODS We analyzed C/EBPalpha expression in 15 human lung cancer cell lines and in 122 human lung primary tumors by northern blotting, immunoblotting, and… CONTINUE READING

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