Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction.

@article{Tabano2010EpigeneticMO,
  title={Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction.},
  author={Silvia Tabano and Patrizia Colapietro and Irene Cetin and Francesca Romana Grati and Susanna Zanutto and Chiara Mand{\`o} and Patrizio Antonazzo and Paola Pileri and Franca Rossella and L Larizza and Silvia Maria Sirchia and Monica Miozzo},
  journal={Epigenetics},
  year={2010},
  volume={5 4},
  pages={313-24}
}
Genomic imprinting, resulting in parent-of-origin-dependent gene expression, is mainly achieved by DNA methylation. IGF2 and H19, belonging to the same cluster of imprinted genes and regulated by ICR1, DMR2 and H19 promoter elements, play a major role in fetal/placental growth. Using quantitative approaches, we explored the epigenetic modulation of IGF2/H19 during human development in 60 normal and 66 idiopathic IUGR (Intrauterine Growth Restriction) pregnancies, studying embryonic (cord blood… CONTINUE READING

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