Epigenetic modulation of seizure-induced neurogenesis and cognitive decline.

  title={Epigenetic modulation of seizure-induced neurogenesis and cognitive decline.},
  author={Sebastian Jessberger and Kinichi Nakashima and Gregory D Clemenson and Eunice Mejia and Emily A Mathews and Kerstin Ure and Shiori Ogawa and Christopher M. Sinton and Fred H. Gage and Jenny Hsieh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={27 22},
The conceptual understanding of hippocampal function has been challenged recently by the finding that new granule cells are born throughout life in the mammalian dentate gyrus (DG). The number of newborn neurons is dynamically regulated by a variety of factors. Kainic acid-induced seizures, a rodent model of human temporal lobe epilepsy, strongly induce the proliferation of DG neurogenic progenitor cells and are also associated with long-term cognitive impairment. We show here that the… CONTINUE READING